Across TCGA pan-cancer cohorts, SPRR4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SPRR4’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPRR4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRR4 is over-expressed in tumor.

LUSC and BRCA are the cancer types where SPRR4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRR4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+1.539	<.001	6	view →
BRCA	Female	All	+0.083	.038	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SPRR4 RNA expression & survival · all SPRR4 data types