Across TCGA patient cohorts, SPRR4 mutation is significantly associated with the RNA expression of many other genes, with 331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRR4-associated genes across cancer lineages are PRAMEF14, RPS3AP17, and RNU6-1315P. Each is linked with SPRR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR4-to-partner and partner-to-SPRR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR4→partner) and Y-score (partner→SPRR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRAMEF14 →	+0.155	+2.666	<.001	.001	3	2
UCEC	RPS3AP17 →	+0.079	+2.999	.005	.001	3	2
UCEC	RNU6-1315P →	+0.326	+2.426	.007	.004	3	2
SKCM	AKAP8L →	+0.339	+3.218	.008	.009	3	1
SKCM	SIN3B →	+0.425	+3.629	.004	.001	3	1
SKCM	EPS15L1 →	+0.361	+3.642	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 331 associations by consensus.

Exploration

SPRR4 survival (RNA) · tumor vs normal (RNA) · all SPRR4 data types