Across TCGA patient cohorts, SPRR4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRR4-associated genes across cancer lineages are Notch1, PAI-1, and Rab25. Each is linked with SPRR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR4-to-partner and partner-to-SPRR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR4→partner) and Y-score (partner→SPRR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.222	+2.817	.002	.036	3	1
UCEC	PAI-1 →	+0.357	+3.169	.047	.019	3	1
UCEC	Rab25 →	-0.450	-3.321	.009	.010	3	1
UCEC	Annexin-1 →	+0.842	+3.321	.002	.010	3	1
SKCM	SF2 →	+0.227	+3.000	.003	.036	2	1
UCEC	eIF4E →	+0.238	+3.000	.031	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

SPRR4 survival (RNA) · tumor vs normal (RNA) · all SPRR4 data types