Across TCGA cell cohorts, SPRR4 RNA expression is significantly associated with the mutation status of many other genes, with 59 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPRR4-associated genes across cancer lineages are CHUK, ZIC4, and NRP1. Each is linked with SPRR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR4-to-partner and partner-to-SPRR4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR4→partner) and Y-score (partner→SPRR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CHUK →	+2.345	+0.055	.007	.001	3	2
OESOPHAGUS	ZIC4 →	+3.584	+1.385	.008	<.001	3	1
LUNG_SCLC	NRP1 →	+4.643	+0.057	.004	<.001	3	1
LARGE_INTESTINE	NCF4 →	+3.345	+0.102	.007	<.001	3	1
LARGE_INTESTINE	LFNG →	+3.930	+0.072	.003	.004	3	1
LARGE_INTESTINE	URGCP →	+2.538	+0.061	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

Exploration

SPRR4 survival (RNA) · tumor vs normal (RNA) · all SPRR4 data types