SPRR3

Across TCGA patient cohorts, SPRR3 mutation is significantly associated with the RNA expression of many other genes, with 370 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR3-associated genes across cancer lineages are DAGLB, SPINDOC, and LRRC20. Each is linked with SPRR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPRR3-to-partner and partner-to-SPRR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAGLB grouped by SPRR3-low versus SPRR3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR3→partner) and Y-score (partner→SPRR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DAGLB →	+0.305	+3.000	.007	<.001	3	2
SKCM	SPINDOC →	+0.518	+2.616	<.001	<.001	3	2
SKCM	LRRC20 →	+0.716	+3.510	<.001	.002	3	2
SKCM	CFL1 →	+0.402	+2.604	.001	<.001	3	2
SKCM	MRPL11 →	+0.365	+2.093	.003	.003	3	2
SKCM	LMNB2 →	+0.529	+2.331	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

DAGLB by SPRR3 expression — SKCM

Explore this box plot interactively →