SPRR2G

Across TCGA pan-cancer cohorts, SPRR2G Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPRR2G data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SPRR2G Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRR2G expression acts as an unfavorable survival marker.

BRCA and LUAD are the cancer types where SPRR2G Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.095	0.903	<.001	12	view →
LUAD	OS	Median	All	0.366	0.686	.012	10	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPRR2G–BRCA (DFS)

Open the BRCA breakdown →