SPRR2G

Across TCGA pan-cancer cohorts, SPRR2G RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPRR2G’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPRR2G RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRR2G is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LUSC, LUAD, and HNSC are the cancer types where SPRR2G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRR2G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+3.624	<.001	6	view →
LUAD	Female	II,III,IV	−0.370	.011	3	view →
HNSC	Male	All	+2.374	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SPRR2G–LUSC

Open the LUSC breakdown →