SPRR2G

Across TCGA patient cohorts, SPRR2G RNA expression is significantly associated with the go_rna of many other GO terms, with 7,026 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR2G-associated GO terms across cancer lineages are Establishment of skin barrier, Skin epidermis development, and Leukocyte aggregation. Each is linked with SPRR2G in more than 9 cancer types. Because this analysis shows association rather than direction, both SPRR2G-to-partner and partner-to-SPRR2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of skin barrier grouped by SPRR2G-low versus SPRR2G-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2G→partner) and Y-score (partner→SPRR2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Establishment of skin barrier →	+0.089	+2.329	<.001	<.001	3	10
ESCA	Skin epidermis development →	+0.051	+2.541	<.001	<.001	3	10
ESCA	Leukocyte aggregation →	+0.080	+2.541	<.001	<.001	3	9
STAD	Ephrin receptor signaling pathway →	+0.053	+0.369	<.001	<.001	3	9
ESCA	Keratinization →	+0.257	+4.591	<.001	<.001	3	9
HNSC	Regulation of antimicrobial humoral response →	+0.103	+3.924	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,026 associations by consensus.

Establishment of skin barrier by SPRR2G expression — ESCA

Explore this box plot interactively →