SPRR2G

Across TCGA patient cohorts, SPRR2G mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR2G-associated genes across cancer lineages are Cyclin-B1, FoxM1, and NF-kB-p65_pS536. Each is linked with SPRR2G in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2G-to-partner and partner-to-SPRR2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by SPRR2G-low versus SPRR2G-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2G→partner) and Y-score (partner→SPRR2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.626	+3.012	.004	.018	3	2
SKCM	FoxM1 →	+0.346	+3.000	.001	.035	3	1
SKCM	NF-kB-p65_pS536 →	+0.586	+3.169	.005	.019	3	1
SKCM	YB-1 →	+0.226	+2.820	.044	.035	2	1
SKCM	eIF4G →	+0.509	+3.169	.018	.019	1	1
SKCM	Rab25 →	-0.314	-3.169	.022	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Cyclin-B1 by SPRR2G expression — SKCM

Explore this box plot interactively →