SPRR2F

Across TCGA patient cohorts, SPRR2F RNA expression is significantly associated with the go_rna of many other GO terms, with 6,900 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR2F-associated GO terms across cancer lineages are Establishment of skin barrier, Leukocyte aggregation, and Autocrine signaling. Each is linked with SPRR2F in more than 11 cancer types. Because this analysis shows association rather than direction, both SPRR2F-to-partner and partner-to-SPRR2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of skin barrier grouped by SPRR2F-low versus SPRR2F-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2F→partner) and Y-score (partner→SPRR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Establishment of skin barrier →	+0.069	+2.973	<.001	<.001	3	11
DLBC	Leukocyte aggregation →	+0.113	+0.110	<.001	.008	1	12
SCLC	Autocrine signaling →	+0.196	+1.946	.003	.001	1	12
ESCA	Regulation of epidermis development →	+0.051	+3.107	<.001	<.001	3	10
ESCA	Keratinization →	+0.239	+4.689	<.001	<.001	3	9
STAD	Protein nitrosylation →	+0.039	+0.592	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,900 associations by consensus.

Establishment of skin barrier by SPRR2F expression — HNSC

Explore this box plot interactively →