SPRR2F

Across TCGA patient cohorts, SPRR2F protein abundance is significantly associated with the RNA expression of many other genes, with 5,482 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR2F-associated genes across cancer lineages are PGLYRP4, CNFN, and PI3. Each is linked with SPRR2F in more than 2 cancer types. Because this analysis shows association rather than direction, both SPRR2F-to-partner and partner-to-SPRR2F results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRR2F versus PGLYRP4 in HNSC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2F→partner) and Y-score (partner→SPRR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PGLYRP4 →	+1.395	+2.017	<.001	<.001	3	3
HNSC	CNFN →	+2.465	+2.197	<.001	<.001	3	3
UCEC	PI3 →	+4.679	+3.759	<.001	<.001	3	3
UCEC	S100A7 →	+4.394	+3.088	.001	<.001	3	3
UCEC	SPINK7 →	+2.357	+3.264	.005	.002	3	3
UCEC	IVL →	+3.565	+3.759	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,482 associations by consensus.

SPRR2F vs PGLYRP4 — HNSC

Explore this scatter interactively →