SPRR2F

Across TCGA cell cohorts, SPRR2F RNA expression is significantly associated with the go_rna of many other GO terms, with 707 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SPRR2F-associated GO terms across cancer lineages are Regulation of intrinsic apoptotic signaling pathway, Regulation of heart rate by cardiac conduction, and Establishment of endothelial intestinal barrier. Each is linked with SPRR2F in more than 4 cancer types. Because this analysis shows association rather than direction, both SPRR2F-to-partner and partner-to-SPRR2F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intrinsic apoptotic signaling pathway grouped by SPRR2F-low versus SPRR2F-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2F→partner) and Y-score (partner→SPRR2F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of intrinsic apoptotic signaling pathway →	+0.044	+0.051	<.001	.001	3	5
LUNG_NSCLC_LUAD	Regulation of heart rate by cardiac conduction →	+0.144	+0.136	<.001	.009	3	4
BLOOD_Leukemia	Establishment of endothelial intestinal barrier →	+0.201	+0.055	<.001	.001	3	4
LUNG_NSCLC_LUAD	Regulation of blood-brain barrier permeability →	+0.172	+0.161	<.001	.005	3	4
LUNG_NSCLC_LUAD	Maintenance of cell polarity →	+0.116	+0.146	<.001	.004	3	4
LUNG_NSCLC_LUAD	Establishment or maintenance of epithelial cell apical/basal polarity →	+0.087	+0.104	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 707 associations by consensus.

Regulation of intrinsic apoptotic signaling pathway by SPRR2F expression — BLOOD_Leukemia

Explore this box plot interactively →