Across TCGA pan-cancer cohorts, SPRR2C Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SPRR2C data layer compared with 12 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SPRR2C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPRR2C expression acts as an unfavorable survival marker.

UCEC are the cancer types where SPRR2C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.061	0.588	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SPRR2C tumor-vs-normal RNA expression · all SPRR2C data types