Across TCGA pan-cancer cohorts, SPRR2C RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SPRR2C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPRR2C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRR2C is over-expressed in tumor.

LUSC are the cancer types where SPRR2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRR2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	+2.878	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SPRR2C RNA expression & survival · all SPRR2C data types