Across TCGA patient cohorts, SPRR2C RNA expression is significantly associated with the go_rna of many other GO terms, with 6,593 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR2C-associated GO terms across cancer lineages are Keratinization, Desmosome organization, and Keratinocyte differentiation. Each is linked with SPRR2C in more than 11 cancer types. Because this analysis shows association rather than direction, both SPRR2C-to-partner and partner-to-SPRR2C results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2C→partner) and Y-score (partner→SPRR2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Keratinization →	+0.256	+4.882	<.001	<.001	3	12
CESC	Desmosome organization →	+0.086	+2.335	<.001	<.001	3	10
ESCA	Keratinocyte differentiation →	+0.093	+4.365	<.001	<.001	3	10
ESCA	Autocrine signaling →	+0.144	+3.862	<.001	<.001	3	10
ESCA	Epidermal cell differentiation →	+0.071	+4.131	<.001	<.001	3	10
ESCA	G protein-coupled purinergic receptor signaling pathway →	+0.108	+3.185	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,593 associations by consensus.

Exploration

SPRR2C survival (RNA) · tumor vs normal (RNA) · all SPRR2C data types