Across TCGA pan-cancer cohorts, SPRR2B Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPRR2B data layer compared with 19 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPRR2B Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPRR2B expression acts as an unfavorable survival marker.

HNSC and LUSC are the cancer types where SPRR2B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.081	0.768	<.001	48	view →
LUSC	OS	Median	All	0.159	0.777	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SPRR2B tumor-vs-normal RNA expression · all SPRR2B data types