SPRR2A

Across TCGA pan-cancer cohorts, SPRR2A mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPRR2A data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPRR2A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SPRR2A expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC and UCEC are the cancer types where SPRR2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.842	0.619	.018	18	view →
UCEC	DFS	Median	All	1.000	0.682	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPRR2A–HNSC (OS)

Open the HNSC breakdown →