SPRR2A

Across TCGA patient cohorts, SPRR2A protein abundance is significantly associated with the RNA expression of many other genes, with 8,522 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SPRR2A-associated genes across cancer lineages are SPRR2E, FSD1, and CNFN. Each is linked with SPRR2A in more than 3 cancer types. Because this analysis shows association rather than direction, both SPRR2A-to-partner and partner-to-SPRR2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPRR2A versus SPRR2E in UCEC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2A→partner) and Y-score (partner→SPRR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPRR2E →	+4.520	+2.482	.007	.001	3	4
LSCC	FSD1 →	-0.667	-1.179	.003	.003	3	3
UCEC	CNFN →	+3.022	+3.145	.004	.002	3	3
UCEC	PI3 →	+6.143	+3.036	.001	.001	3	3
UCEC	LYPD3 →	+3.710	+3.234	<.001	.004	3	3
UCEC	BTN2A2 →	-0.779	-1.994	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,522 associations by consensus.

SPRR2A vs SPRR2E — UCEC

Explore this scatter interactively →