SPRR2A

Across TCGA cell cohorts, SPRR2A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,470 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SPRR2A-associated GO terms across cancer lineages are Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity, Regulation of intrinsic apoptotic signaling pathway, and Response to mycotoxin. Each is linked with SPRR2A in more than 6 cancer types. Because this analysis shows association rather than direction, both SPRR2A-to-partner and partner-to-SPRR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity grouped by SPRR2A-low versus SPRR2A-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2A→partner) and Y-score (partner→SPRR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity →	+0.151	+0.735	<.001	.007	3	7
PANCREAS	Regulation of intrinsic apoptotic signaling pathway →	+0.064	+2.797	<.001	.001	3	7
PANCREAS	Response to mycotoxin →	+0.307	+1.679	.002	.001	3	7
STOMACH	Negative regulation of defense response →	+0.058	+0.438	<.001	.001	3	7
PANCREAS	Negative regulation of innate immune response →	+0.097	+1.916	<.001	.005	3	7
KIDNEY	Cellular response to indole-3-methanol →	+0.123	+0.030	.002	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,470 associations by consensus.

Positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity by SPRR2A expression — BREAST

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