SPRR1A

Across TCGA patient cohorts, SPRR1A mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRR1A-associated genes across cancer lineages are MTND5P3, KRT90P, and MIR548AQ. Each is linked with SPRR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR1A-to-partner and partner-to-SPRR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P3 grouped by SPRR1A-low versus SPRR1A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR1A→partner) and Y-score (partner→SPRR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTND5P3 →	+0.033	+5.217	.007	.007	3	1
LUAD	KRT90P →	+0.063	+5.984	<.001	.002	3	1
UCEC	MIR548AQ →	+0.536	+3.294	.007	.007	3	1
UCEC	COX6CP3 →	+0.268	+3.677	<.001	.001	3	1
UCEC	ATP6V1E1P2 →	+0.407	+3.077	<.001	.005	3	1
UCEC	PSMD7P1 →	+0.414	+2.976	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

MTND5P3 by SPRR1A expression — LUAD

Explore this box plot interactively →