Across TCGA patient cohorts, SPRN RNA expression is significantly associated with the protein abundance of many other proteins, with 10,429 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPRN-associated proteins across cancer lineages are TRADD, NAT1, and PARP4. Each is linked with SPRN in more than 3 cancer types. Because this analysis shows association rather than direction, both SPRN-to-partner and partner-to-SPRN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRN→partner) and Y-score (partner→SPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRADD →	-0.248	-0.383	.007	.003	3	4
GBM	NAT1 →	-0.554	-0.529	<.001	<.001	3	4
GBM	PARP4 →	-0.345	-0.384	<.001	<.001	3	4
LSCC	SF3B3 →	+0.161	+0.333	.003	.002	3	4
UCEC	HNRNPU →	+0.164	+0.421	.002	.004	3	4
PDAC	S100A9 →	-0.981	-0.231	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,429 associations by consensus.

Exploration

SPRN survival (RNA) · tumor vs normal (RNA) · all SPRN data types