Across TCGA pan-cancer cohorts, SPRN RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SPRN data layer compared with 1 for mass-spec protein.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SPRN RNA is associated with better overall survival. In most high-consensus cancer types, elevated SPRN expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.
BLCA, PAAD, and UVM are the cancer types where SPRN RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.