Across TCGA patient cohorts, SPRN mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRN-associated genes across cancer lineages are RNVU1-31, IGKV1OR2-118, and SNORD11B. Each is linked with SPRN in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRN-to-partner and partner-to-SPRN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRN→partner) and Y-score (partner→SPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNVU1-31 →	+0.941	+2.780	.007	.008	3	1
UCEC	IGKV1OR2-118 →	+0.318	+2.759	<.001	.002	3	1
UCEC	SNORD11B →	+0.873	+3.476	<.001	<.001	3	1
UCEC	H4C13 →	+0.895	+2.917	<.001	.005	3	1
UCEC	STMN1P1 →	+0.558	+3.332	<.001	.005	3	1
UCEC	RNVU1-28 →	+1.071	+2.442	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

Exploration

SPRN survival (RNA) · tumor vs normal (RNA) · all SPRN data types