Across TCGA cell cohorts, SPRN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,063 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPRN-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Pre-mRNA catabolic process. Each is linked with SPRN in more than 16 cancer types. Because this analysis shows association rather than direction, both SPRN-to-partner and partner-to-SPRN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRN→partner) and Y-score (partner→SPRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Viral translational termination-reinitiation →	+0.093	+1.027	<.001	<.001	3	17
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.171	+0.657	<.001	<.001	3	16
BONE	Pre-mRNA catabolic process →	+0.240	+0.836	<.001	<.001	3	16
SOFT_TISSUE	Regulation of DNA repair →	+0.088	+1.046	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.098	+1.258	<.001	<.001	3	16
BONE	Negative regulation of DNA-templated transcription, elongation →	+0.127	+0.704	.003	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,063 associations by consensus.

Exploration

SPRN survival (RNA) · tumor vs normal (RNA) · all SPRN data types