Across TCGA patient cohorts, SPRED3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,578 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPRED3-associated proteins across cancer lineages are SPARC, CRTAP, and MRC2. Each is linked with SPRED3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPRED3-to-partner and partner-to-SPRED3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED3→partner) and Y-score (partner→SPRED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPARC →	+0.738	+0.696	<.001	<.001	3	8
OV	CRTAP →	+0.515	+0.515	<.001	<.001	3	8
GBM	MRC2 →	+0.614	+1.136	<.001	<.001	3	8
OV	P3H3 →	+0.642	+0.666	<.001	<.001	3	8
CCRCC	SRPX2 →	+0.869	+0.375	<.001	<.001	3	7
PDAC	COL12A1 →	+0.667	+0.369	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,578 associations by consensus.

Exploration

SPRED3 survival (RNA) · tumor vs normal (RNA) · all SPRED3 data types