Across TCGA patient cohorts, SPRED3 protein abundance is significantly associated with the RNA expression of many other genes, with 2,191 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPRED3-associated genes across cancer lineages are SEC14L2, CYTH4, and ESS2. Each is linked with SPRED3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED3-to-partner and partner-to-SPRED3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED3→partner) and Y-score (partner→SPRED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC14L2 →	+0.572	+0.578	.001	.001	3	1
GBM	CYTH4 →	+0.792	+0.643	.002	.003	3	1
GBM	ESS2 →	-0.369	-0.574	.001	<.001	3	1
GBM	CRYBB2P1 →	-0.330	-0.430	.002	.002	3	1
GBM	HIRA →	-0.317	-0.631	.001	.001	3	1
GBM	HPS4 →	-0.349	-0.535	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,191 associations by consensus.

Exploration

SPRED3 survival (RNA) · tumor vs normal (RNA) · all SPRED3 data types