Across TCGA cell cohorts, SPRED3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,935 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPRED3-associated GO terms across cancer lineages are Positive regulation of ubiquitin-dependent protein catabolic process, Regulation of respiratory gaseous exchange by nervous system process, and Protein deneddylation. Each is linked with SPRED3 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPRED3-to-partner and partner-to-SPRED3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED3→partner) and Y-score (partner→SPRED3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of ubiquitin-dependent protein catabolic process →	+0.070	+0.879	.009	.002	3	12
URINARY_TRACT	Regulation of respiratory gaseous exchange by nervous system process →	+1.079	+1.298	<.001	<.001	3	11
BREAST	Protein deneddylation →	+0.102	+0.669	<.001	.001	3	11
BREAST	Lipoprotein localization →	+0.132	+0.961	<.001	<.001	3	11
LUNG_SCLC	Vacuole organization →	+0.032	+0.921	.002	<.001	3	11
OESOPHAGUS	Regulation of cilium assembly →	+0.069	+1.060	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,935 associations by consensus.

Exploration

SPRED3 survival (RNA) · tumor vs normal (RNA) · all SPRED3 data types