Across TCGA patient cohorts, SPRED2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,734 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPRED2-associated genes across cancer lineages are EHD4, LIMK1, and LUC7L3. Each is linked with SPRED2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRED2-to-partner and partner-to-SPRED2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRED2→partner) and Y-score (partner→SPRED2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EHD4 →	+0.699	+0.655	.007	<.001	3	2
BRCA	LIMK1 →	+1.308	+0.749	.002	<.001	3	2
GBM	LUC7L3 →	-0.392	-0.289	<.001	.001	3	2
BRCA	RPAIN →	-1.266	-0.939	<.001	<.001	3	2
BRCA	ZNF287 →	-0.829	-0.623	<.001	.002	3	2
BRCA	PRPSAP2 →	-0.927	-0.902	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,734 associations by consensus.

Exploration

SPRED2 survival (RNA) · tumor vs normal (RNA) · all SPRED2 data types