SPR

Across TCGA patient cohorts, SPR mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPR-associated genes across cancer lineages are MIR1273H, RNU6-630P, and ELOCP4. Each is linked with SPR in more than 1 cancer types. Because this analysis shows association rather than direction, both SPR-to-partner and partner-to-SPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1273H grouped by SPR-low versus SPR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPR→partner) and Y-score (partner→SPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1273H →	+0.702	+5.621	<.001	.004	3	1
BRCA	RNU6-630P →	+0.376	+8.055	<.001	.007	3	1
BRCA	ELOCP4 →	+0.074	+8.471	<.001	.005	3	1
BRCA	USP9YP32 →	+0.059	+8.471	<.001	.005	3	1
BRCA	RNU6-300P →	+0.216	+7.731	<.001	.009	3	1
BRCA	RNU6-488P →	+0.284	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MIR1273H by SPR expression — UCEC

Explore this box plot interactively →