SPR

Across TCGA pan-cancer cohorts, SPR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPR data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SPR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPR expression acts as an unfavorable survival marker, although some lineages such as STAD and BRCA show a favorable association.

UCS, ESCA, and COAD are the cancer types where SPR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.557	0.916	<.001	132	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	52	view →
COAD	DFS	Tertile	II,III,IV	0.357	0.766	<.001	42	view →
LUAD	DFS	Quartile	All	0.319	0.730	.002	37	view →
STAD	DFS	Tertile	II,III,IV	0.632	0.443	.006	26	view →
GBM	OS	Median	All	0.267	0.577	<.001	24	view →
HNSC	DFS	Median	All	0.655	0.733	.007	24	view →
PAAD	DFS	Tertile	II,III,IV	0.359	0.545	.018	20	view →
THCA	DFS	Median	II,III,IV	0.800	0.935	.008	20	view →
SKCM	OS	Median	IV	0.273	0.727	.011	16	view →
BRCA	OS	Tertile	III,IV	0.693	0.493	.022	14	view →
SARC	DFS	Tertile	All	0.412	0.247	.003	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPR–UCS (OS)

Open the UCS breakdown →