SPR

Across TCGA cell cohorts, SPR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,078 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPR-associated GO terms across cancer lineages are Tetrahydrobiopterin metabolic process, Tetrahydrobiopterin biosynthetic process, and Pteridine-containing compound biosynthetic process. Each is linked with SPR in more than 12 cancer types. Because this analysis shows association rather than direction, both SPR-to-partner and partner-to-SPR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tetrahydrobiopterin metabolic process grouped by SPR-low versus SPR-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPR→partner) and Y-score (partner→SPR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Tetrahydrobiopterin metabolic process →	+0.137	+1.149	<.001	.001	3	13
BONE	Tetrahydrobiopterin biosynthetic process →	+0.170	+1.001	.002	<.001	3	12
SKIN	Pteridine-containing compound biosynthetic process →	+0.131	+0.744	<.001	.001	3	10
LIVER	Monocarboxylic acid catabolic process →	+0.084	+1.253	.008	.001	3	9
BLOOD_Leukemia	Nucleoside triphosphate biosynthetic process →	+0.070	+1.780	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Purine nucleoside triphosphate metabolic process →	+0.077	+0.846	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,078 associations by consensus.

Tetrahydrobiopterin metabolic process by SPR expression — URINARY_TRACT

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