Across TCGA cell cohorts, SPPL2C mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPPL2C-associated genes across cancer lineages are OR1A1, NUBP1, and CACYBP. Each is linked with SPPL2C in more than 1 cancer types. Because this analysis shows association rather than direction, both SPPL2C-to-partner and partner-to-SPPL2C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPPL2C→partner) and Y-score (partner→SPPL2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR1A1 →	+0.006	+5.209	<.001	.005	3	1
LARGE_INTESTINE	NUBP1 →	+0.409	+3.364	.005	.002	3	1
LARGE_INTESTINE	CACYBP →	+0.486	+3.364	.008	.002	3	1
LARGE_INTESTINE	ARL1 →	+0.565	+3.304	.001	.005	3	1
LARGE_INTESTINE	NDUFAF4 →	+0.650	+3.364	.001	.002	3	1
LARGE_INTESTINE	PCNA →	+0.663	+3.169	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

Exploration

SPPL2C survival (RNA) · tumor vs normal (RNA) · all SPPL2C data types