SPP1

Across TCGA pan-cancer cohorts, SPP1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SPP1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SPP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SPP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where SPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.264	0.490	.006	52	view →
CCRCC	DFS	Median	II,III,IV	0.419	0.819	<.001	49	view →
HNSC	DFS	Median	All	0.894	0.667	.002	35	view →
LUAD	DFS	Tertile	All	0.508	0.795	.003	27	view →
GBM	OS	Quartile	All	0.349	0.592	.007	10	view →
OV	DFS	Median	All	0.880	0.597	.024	8	view →
UCEC	DFS	Median	III,IV	0.889	0.460	.044	4	view →
LSCC	OS	Median	All	0.793	1.000	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SPP1–PDAC (OS)

Open the PDAC breakdown →