SPP1

Across TCGA patient cohorts, SPP1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,306 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPP1-associated genes across cancer lineages are GBE1, HK2, and P4HA1. Each is linked with SPP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPP1-to-partner and partner-to-SPP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPP1 versus GBE1 in GBM, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP1→partner) and Y-score (partner→SPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GBE1 →	+0.661	+0.699	<.001	.002	3	5
GBM	HK2 →	+1.256	+1.261	<.001	<.001	3	5
LUAD	P4HA1 →	+0.880	+0.938	<.001	<.001	3	5
LUAD	PLOD2 →	+1.114	+0.918	<.001	<.001	3	5
HNSC	RAB3IL1 →	+0.537	+0.650	.001	.002	3	5
CCRCC	TGFBI →	+1.628	+0.644	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,306 associations by consensus.

SPP1 vs GBE1 — GBM

Explore this scatter interactively →