SPP1

Across TCGA patient cohorts, SPP1 mutation is significantly associated with the RNA expression of many other genes, with 3,344 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPP1-associated genes across cancer lineages are RN7SL551P, TRAJ58, and DCP1A. Each is linked with SPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPP1-to-partner and partner-to-SPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL551P grouped by SPP1-low versus SPP1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP1→partner) and Y-score (partner→SPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL551P →	+0.084	+4.384	<.001	.008	3	3
CESC	TRAJ58 →	+0.485	+3.874	<.001	.006	3	2
UCEC	DCP1A →	+0.618	+2.724	<.001	.003	3	2
UCEC	SSRP1 →	+0.632	+2.606	<.001	<.001	3	2
UCEC	MRPL49 →	+0.552	+2.823	.001	.001	3	2
UCEC	TBRG1 →	+0.409	+2.638	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,344 associations by consensus.

RN7SL551P by SPP1 expression — CESC

Explore this box plot interactively →