SPP1

Across TCGA patient cohorts, SPP1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPP1-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and A-Raf_pS299. Each is linked with SPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPP1-to-partner and partner-to-SPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by SPP1-low versus SPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP1→partner) and Y-score (partner→SPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.585	+3.321	.010	.009	3	2
UCEC	EGFR_pY1068 →	-0.257	-3.169	.015	.019	3	1
UCEC	A-Raf_pS299 →	-0.141	-2.321	.005	.034	3	1
UCEC	Heregulin →	-0.165	-2.584	.001	.010	3	1
UCEC	JNK2 →	+0.273	+3.009	.001	.019	3	1
UCEC	Ku80 →	+0.321	+2.235	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GAPDH by SPP1 expression — UCEC

Explore this box plot interactively →