SPP1

Across TCGA cell cohorts, SPP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,012 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPP1-associated GO terms across cancer lineages are Positive regulation of steroid hormone secretion, Androgen catabolic process, and Negative regulation of axon regeneration. Each is linked with SPP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SPP1-to-partner and partner-to-SPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of steroid hormone secretion grouped by SPP1-low versus SPP1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP1→partner) and Y-score (partner→SPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of steroid hormone secretion →	+1.285	+6.777	.001	<.001	3	13
CNS	Androgen catabolic process →	+0.405	+2.684	<.001	<.001	3	13
SKIN	Negative regulation of axon regeneration →	+0.138	+2.875	<.001	<.001	3	12
SOFT_TISSUE	Regulation of steroid hormone secretion →	+0.268	+5.606	<.001	<.001	3	11
OVARY	Positive regulation of bone resorption →	+0.215	+5.337	<.001	<.001	3	10
STOMACH	Negative regulation of collateral sprouting →	+1.166	+3.220	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,012 associations by consensus.

Positive regulation of steroid hormone secretion by SPP1 expression — LUNG_NSCLC_LUSC

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