SPP1

Across TCGA cell cohorts, SPP1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPP1-associated genes across cancer lineages are GML, TSHB, and OR56A4. Each is linked with SPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPP1-to-partner and partner-to-SPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by SPP1-low versus SPP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPP1→partner) and Y-score (partner→SPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.078	+4.152	<.001	.009	3	1
BLOOD_Leukemia	TSHB →	+0.125	+4.276	.004	.007	3	1
BLOOD_Leukemia	OR56A4 →	+0.011	+4.874	<.001	.002	3	1
BLOOD_Leukemia	KRT40 →	+0.017	+4.152	.002	.009	3	1
BLOOD_Leukemia	KRTAP4-11 →	+0.022	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OC90 →	+0.012	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GML by SPP1 expression — BLOOD_Leukemia

Explore this box plot interactively →