SPOPL

Across TCGA cell cohorts, SPOPL mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPOPL-associated genes across cancer lineages are STATH, OR1L3, and UCN3. Each is linked with SPOPL in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOPL-to-partner and partner-to-SPOPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STATH grouped by SPOPL-low versus SPOPL-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOPL→partner) and Y-score (partner→SPOPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STATH →	+0.388	+4.643	<.001	.003	3	1
SKIN	OR1L3 →	+0.029	+5.415	<.001	.004	3	1
SKIN	UCN3 →	+0.031	+4.977	<.001	.007	3	1
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
LARGE_INTESTINE	KCNA5 →	+0.011	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLC35G3 →	+0.011	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

STATH by SPOPL expression — CNS

Explore this box plot interactively →