SPOP

Across TCGA cell cohorts, SPOP mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPOP-associated genes across cancer lineages are GLRA4, OTUD6A, and KRTAP17-1. Each is linked with SPOP in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOP-to-partner and partner-to-SPOP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLRA4 grouped by SPOP-low versus SPOP-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOP→partner) and Y-score (partner→SPOP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GLRA4 →	+0.039	+3.700	<.001	.005	3	1
OVARY	OTUD6A →	+0.015	+3.990	<.001	.003	3	1
SKIN	KRTAP17-1 →	+0.025	+4.977	<.001	.007	3	1
SKIN	FABP12 →	+0.148	+5.415	<.001	.004	3	1
SKIN	TMEM211 →	+0.121	+4.977	<.001	.007	3	1
SKIN	SPRR5 →	+0.416	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GLRA4 by SPOP expression — OVARY

Explore this box plot interactively →