SPON1

Across TCGA pan-cancer cohorts, SPON1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SPON1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SPON1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPON1 expression acts as an unfavorable survival marker, although some lineages such as OV and LUAD show a favorable association.

LSCC, PDAC, and OV are the cancer types where SPON1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	17	view →
PDAC	DFS	Median	III,IV	0.158	0.508	.009	5	view →
OV	DFS	Median	All	1.000	0.853	.030	4	view →
UCEC	OS	Tertile	II,III,IV	0.627	1.000	.045	4	view →
LUAD	DFS	Tertile	All	0.786	0.529	.011	3	view →
CCRCC	OS	Tertile	All	1.000	0.668	.043	1	view →
GBM	DFS	Quartile	All	0.778	0.528	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SPON1–LSCC (DFS)

Open the LSCC breakdown →