SPON1

Across TCGA pan-cancer cohorts, SPON1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SPON1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPON1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPON1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, BLCA, and COAD are the cancer types where SPON1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPON1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−4.522	<.001	9	view →
BLCA	Male	All	−3.461	<.001	8	view →
COAD	Female	II,III,IV	−1.561	<.001	7	view →
LUSC	Male	II,III,IV	−1.441	<.001	6	view →
HNSC	Female	III,IV	+1.841	.012	5	view →
BRCA	All	All	−0.468	.001	4	view →
READ	All	All	−2.761	<.001	3	view →
STAD	All	All	−1.194	.017	3	view →
LUAD	Female	III,IV	−0.854	.006	3	view →
UCEC	All	All	−2.534	<.001	2	view →
KIRC	Male	II,III,IV	−1.353	.009	2	view →
PRAD	All	All	−1.124	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SPON1–KICH

Open the KICH breakdown →