SPON1

Across TCGA patient cohorts, SPON1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPON1-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and eIF4G. Each is linked with SPON1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPON1-to-partner and partner-to-SPON1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SPON1-low versus SPON1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPON1→partner) and Y-score (partner→SPON1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.079	-2.673	.010	.005	3	2
UCEC	eIF4E →	+0.157	+2.713	.015	.003	3	2
UCEC	eIF4G →	+0.208	+1.807	.028	.024	3	2
UCEC	MEK1 →	+0.297	+1.662	.007	.010	3	2
UCEC	p62 Lck ligand →	+0.369	+3.087	<.001	<.001	3	2
UCEC	PCNA →	+0.246	+2.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

14-3-3_beta by SPON1 expression — UCEC

Explore this box plot interactively →