SPON1-AS1

Across TCGA pan-cancer cohorts, SPON1-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SPON1-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SPON1-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPON1-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and HNSC show a favorable association.

KIRP, HNSC, and COAD are the cancer types where SPON1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.846	0.454	<.001	91	view →
HNSC	OS	Tertile	III,IV	0.809	0.677	.007	51	view →
COAD	OS	Tertile	IV	0.257	0.590	.005	50	view →
LIHC	DFS	Tertile	All	0.433	0.598	<.001	42	view →
THCA	OS	Quartile	III,IV	0.855	0.979	.002	37	view →
KIRC	OS	Median	II,III,IV	0.629	0.759	.003	27	view →
UCEC	OS	Quartile	All	0.666	0.779	.007	24	view →
PCPG	OS	Quartile	All	0.761	1.000	.004	21	view →
CHOL	OS	Tertile	All	1.000	0.214	.008	17	view →
SARC	DFS	Tertile	All	0.601	0.188	.001	15	view →
UVM	DFS	Tertile	III,IV	0.183	0.802	.003	14	view →
LUAD	DFS	Tertile	IV	0.459	0.826	.015	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SPON1-AS1–KIRP (DFS)

Open the KIRP breakdown →