SPON1-AS1

Across TCGA pan-cancer cohorts, SPON1-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPON1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SPON1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPON1-AS1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

KIRP, BRCA, and KIRC are the cancer types where SPON1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPON1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	+0.618	<.001	7	view →
BRCA	All	III,IV	−0.525	<.001	6	view →
KIRC	All	All	+0.185	.004	6	view →
BLCA	Male	All	−0.485	.007	5	view →
COAD	Female	IV	−0.435	.003	5	view →
HNSC	All	All	+0.143	.016	5	view →
LUSC	Female	All	−0.532	<.001	4	view →
READ	All	II,III,IV	−0.670	.006	3	view →
KICH	All	All	−0.273	.013	2	view →
THCA	All	All	−0.191	.001	2	view →
LIHC	All	All	+0.127	.002	2	view →
LUAD	All	III,IV	−0.393	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPON1-AS1–KIRP

Open the KIRP breakdown →