Across TCGA patient cohorts, SPOCK3 mutation is significantly associated with the RNA expression of many other genes, with 3,765 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOCK3-associated genes across cancer lineages are IGLVVII-41-1, JPT2, and MAOB. Each is linked with SPOCK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPOCK3-to-partner and partner-to-SPOCK3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK3→partner) and Y-score (partner→SPOCK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	IGLVVII-41-1 →	+0.212	+4.618	<.001	.005	3	3
SKCM	JPT2 →	+0.317	+1.748	.001	<.001	3	3
SKCM	MAOB →	-0.990	-1.637	.004	.009	3	3
UCEC	EI24 →	+0.514	+3.643	<.001	<.001	3	3
UCEC	CCDC15 →	+0.360	+2.169	.002	<.001	3	3
UCEC	BUB3 →	+0.540	+4.075	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,765 associations by consensus.

Exploration

SPOCK3 survival (RNA) · tumor vs normal (RNA) · all SPOCK3 data types