SPNS3

Across TCGA patient cohorts, SPNS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,363 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPNS3-associated proteins across cancer lineages are COTL1, CLPX, and COL14A1. Each is linked with SPNS3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPNS3-to-partner and partner-to-SPNS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPNS3 versus COTL1 in LSCC, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS3→partner) and Y-score (partner→SPNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	COTL1 →	+0.628	+0.476	<.001	<.001	3	8
LUAD	CLPX →	-0.354	-0.511	<.001	<.001	3	6
BRCA	COL14A1 →	+1.115	+0.411	<.001	<.001	3	6
GBM	CRYL1 →	+0.412	+0.377	.002	.003	3	6
LSCC	DOCK10 →	+0.522	+0.398	<.001	<.001	3	6
BRCA	HEATR1 →	-0.380	-0.315	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,363 associations by consensus.

SPNS3 vs COTL1 — LSCC

Explore this scatter interactively →