SPNS3

Across TCGA pan-cancer cohorts, SPNS3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPNS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPNS3 RNA is repressed in tumor relative to normal tissue. In most cancer types SPNS3 is over-expressed in tumor, although a few such as KICH and HNSC show the opposite, repressed pattern.

KICH, COAD, and HNSC are the cancer types where SPNS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPNS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−2.486	<.001	11	view →
COAD	Female	III,IV	+1.242	<.001	11	view →
HNSC	Male	II,III,IV	−0.711	<.001	11	view →
LUSC	Male	II,III,IV	−0.965	<.001	8	view →
UCEC	All	All	−0.929	<.001	4	view →
LIHC	Female	All	+0.629	.020	4	view →
STAD	All	All	+0.495	.003	4	view →
BRCA	Female	II,III,IV	−0.246	<.001	4	view →
CHOL	All	All	+1.072	<.001	3	view →
READ	All	All	+0.855	.002	2	view →
THCA	All	IV	+0.360	.003	2	view →
PRAD	All	All	−0.253	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPNS3–KICH

Open the KICH breakdown →