SPNS3

Across TCGA patient cohorts, SPNS3 mutation is significantly associated with the RNA expression of many other genes, with 2,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPNS3-associated genes across cancer lineages are ELAC2, FDFT1, and MED15P4. Each is linked with SPNS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPNS3-to-partner and partner-to-SPNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELAC2 grouped by SPNS3-low versus SPNS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS3→partner) and Y-score (partner→SPNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELAC2 →	+0.392	+2.847	.001	.001	3	3
UCEC	FDFT1 →	+0.594	+3.480	<.001	.002	3	3
LUAD	MED15P4 →	+0.307	+4.629	.001	.001	3	3
UCEC	MYO19 →	+0.532	+2.971	<.001	<.001	3	3
UCEC	RTCB →	+0.496	+2.861	.001	.001	3	3
UCEC	MIR425 →	+0.310	+2.084	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,836 associations by consensus.

ELAC2 by SPNS3 expression — UCEC

Explore this box plot interactively →