SPNS3

Across TCGA patient cohorts, SPNS3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPNS3-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4G. Each is linked with SPNS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS3-to-partner and partner-to-SPNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SPNS3-low versus SPNS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS3→partner) and Y-score (partner→SPNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.354	+2.584	.007	.010	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.321	.003	.005	3	2
UCEC	eIF4G →	+0.273	+2.115	.016	.017	3	2
UCEC	GATA6 →	-0.119	-3.155	.045	.018	3	2
UCEC	Annexin-1 →	+0.574	+2.604	.002	.005	3	2
UCEC	Smad3 →	+0.114	+2.000	.039	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eEF2 by SPNS3 expression — UCEC

Explore this box plot interactively →